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CyFlow™ ARHGEF4 PE
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Target Species: | Human |
| Regulatory Status: | RUO |
| Laser: | Blue, Green, Yellow |
| Source Species: | Mouse |
| Format/Fluorochrome: | PE |
| Excitation Maximum: | 496 nm, 565 nm |
| Emission Maximum: | 576 nm |
| Isotype: | IgG1 |
| Field of Interest: | Signaling |
| Antigen: | ARHGEF4 |
| Clone: | ARHGEF-08 |
| Order number: | BV459562 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 0,1 Quantity 0.1 mg Volume 1.0 mL... more
Product information "CyFlow™ ARHGEF4 PE"
| Concentration Unit | mg/mL |
| Concentration | 0,1 |
| Quantity | 0.1 mg |
| Volume | 1.0 mL |
| Immunogen | Recombinant fragment of human ARHGEF4 (amino acids 143-271) |
| Background Information | ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF1 (Adenomatous polyposis coli - stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration. |
| Usage | The reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator. |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Technical Data Sheet
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